Exactly Bodhi! | |
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I think we all are old enough to look at the research that is being done and forming our own opinions on said research.
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Yes but... everyone's posts are just speculation, correct? | |
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Posts about scientific topics -- how drugs interact with the body and each other, for example -- are not just "speculation." They can and should be backed up with emperical sources and we should all be open to people saying that the sources or info we provide might be wrong. I'm not clear why we're obligated to agree that what Menes has posted about the effects of various drugs, say, is true, just because his posts are long and/or use scientific lingo - Even "speculation" can and should be backed up with some kind of sources. In other words, some sort of information led someone to speculate that something might be true. It didn't just emerge from the ether.
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Actually the most offensive thing I've seen lately here was this recent comment by Menes direct at another poster who Menes implies had revealed some kind of struggle with drug dependency/addiction (Menes posted this when the other poster simply provided some facts about lidocaine that contadicted what Menes has posted). I'd be curious to see how ANYONE thinks this is an acceptable thing to say: - "Your claim to fame on this board is that you are an addict(?) This is neither challenging, nor is it an accomplishment I would wish to obtain one day. Your brain will always function primarily as a defense shield, absorbing nothing but rehashed transmissions that feed your existence. It has been battered and bruised, and quite frankly, permanently damaged. As any scholarly person will tell you, your brain is now wired to be beyond reproach, because you see, you are essentially what the drug has made you."
[Edited 6/30/18 17:49pm] | |
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I've read all posts on this thread. I take in account what Menes, and Rebel says. I don't discount either of them. We all are able to make our own conclusions. How many times have I said, that if some of those pills were just lidocaine, then P got taken. How many times have I stated that l thought lidocaine was just a cheap filler? Menes made a point about why he thought lidocaine was mixed in based on his knowledge. Rebel made a point on why he thought lidocaine wasn't used as a withdrawel agent.
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A little hyperbolic, are we? | |
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Penny, it's not just 2 people "laying out what they know." This particular discussions are questions of scientific fact, not opinion. - And the issue isn't "professing your profession," which you've mentioned over and over. It's about establishing the source of your information, whether that source is first-hand experience (such as what you acquired in your job), or credible documents you've read. Either way, especially when discussing scientific topics, people should be transparent about that. - Menes' discussion about lidocaine etc. isn't coming from the investigation files. What he has said repeatedly that is from the files -- claiming that Dr S prescribed Prince lidocaine for withdrawal, and using that as evidence that lidocaine is an valid opioid-withdrawal treatement -- is simply false. - Edited to add: I generally appreciate your posts penny. It was a little frustrating to see this whole thread being taken over by Menes' theories which I've taken the time to look into and appear very very shaky to me. And I'm sure he'll be back any moment and unleash insults on anyone who dared to question him, and then i'll go bye-bye!
[Edited 6/30/18 18:23pm] | |
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One would think. Then why the offense from some when what they write is questioned or slinging shit at someone else's response? | |
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You know, I have to give it to the local LE officers. At the scene, they did everything they could to protect Prince's privacy. Made sure nobody took unauthorized pics. the pics they did have were for the investigation and when printed were counted before giving them to detectives, etc and counted when they were returned. They were discreet when removing him from the building even to the point of sending a decoy vehicle. They handled the media and mourners well. | |
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Kim Pratt mentioned 2 other body guards, a Julius, and Shaun. I imagine that was Shaun Powell which was KJ's nephew. I thought Shaun was the groundskeeper. | |
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Hi everyone, I usually just read on here and never comment. The hostility towards others on here is really annoying sometimes. Only for that specific reason I will disclose my occupation and contribute to the lidocaine/opioid-antagonist dispute. Being an anaesthesiologist in a university hospital for almost 20 years I may have some sort of expertise on this conflict. This doesn´t mean that I can answer the questions of why?, what were the sources?, how much was ingested? and the such.
Lidocaine is a blocker of voltage dependent sodium channels of nerve cell membranes. Orally ingested, its bioavailability is 35% at best, that´s why it´s used either as a local anaesthetic or an iv antiarrhythmic agent a) as a topic spray or gel, for example: sore throat; reducing the excitability of the glottis before intubation; specific galenic formulation which penetrates the skin in order to reduce the local pain of iv injections in children; etc. b) infiltrated subcutaneously or in direct proximity of nerves for providing nerve blocks c) iv as an antiarrhythmic (class Ib) since the cardiac conduction system consists of nerve cells d) iv during and after intraabdominal surgeries for pain relief if an epidural catheter is not applicable It does not come in pill form since the first pass metabolism of the liver will eliminate most of it without showing up in systemic circulation. Without injecting, one can only hit high systemic levels when either overusing the topic spray since mucuous membranes resorbe it quickly and very well or swallowing a great amount of the spray or gel. The clinical manifestation would be cardiac arrhythmias or/and epileptic seizures if the levels are high. Sub-intoxicating levels may show in vertigo, dizziness, maybe sedation. It doesn´t have any opioid-antagonist properties. I have never heard of it´s use as an anti-withdrawal-symptom-medication. In the country I am from, anaesthesiologists also work as pain management doctors, don´t know about the US, I´m from Europe.
An opioid-antagonist (like Naloxon) has to be injected since it´s first pass metabolism after oral use is even higher than the one following lidocaine, it´s 98% I believe. In EU, fix combinations of opioids plus antagonist (Tilidin + Naloxon or Oxycodon + Naloxon) are available in pill form since the Naloxon is not resorbed orally and prevents the abdominal side effect of constipation, and to prevent people to solubilize and inject these formulations since the Naloxon would bring the user in withdrawals. | |
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OPINION (!) of a person with job-related background on opioids: 1) long term user with usually good knowledge about familiar substance/mix 2) for whichever reason in accelerated downward spiral, affecting the thoughtfulness concerning suppliers/ change of supplier maybe/ feeding habits 3) no actual scientific knowledge of the composition of the pills/the cutting agents/fillers/lacing with fentanyl -> feeling smart enough to handle it 4) state of denial if he knew it was fentanyl/ accepting the consequences of overdosing again with lethal outcome seemed to be easier than facing the truth/ not being able to take the image-loss
The just Lidocaine batch was maybe a cheap bargain or whatever, suppliers possibly assume that users will mix it anyhow so will have some kind of effect. This is an assumption for my part.
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To bring up an old refrain: can we all just get along? I greatly appreciate the time and effort many orgers have put into examining the documents released thus far. However, I don't think it takes a review board to authorize posts to this site. Each of us has an opinion, which we are entitled to express - courteously and with sound reasoning. Most of the crazies seem to have gone away, with the rest of us earnestly trying to fathom how this brilliant man apparently led a secret life unknown to his millions of fans but known to those in infrequent contact with him as well as people in the music industry. | |
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Also this, from online resource from Boston University's School of Medicine, Pharmacology and Experimental Therapeutics: "Glossary of Terms and Symbols Used in Pharmacology" The joint effect of two or more drugs such that the combined effect is less than the sum of the effects produced by each agent separately. The agonist is the agent producing the effect that is diminished by the administration of the antagonist. Antagonisms may be any of three general types:
In the case of pharmacological antagonisms, the terms competitive and non-competitive antagonism are used with meanings analogous to competitive and non-competitive enzyme inhibition as used in enzymology. (See Symposium on Drug Antagonism, Pharm. Rev. 9: 211, 1952). | |
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Yeah several here have also mentioned that maybe he couldn't handle the image loss. Which is really sad because people go to rehab everyday to get help. I also think he could have gone anywhere in the world to get that help, and the fans would know nothing other then he was vacationing or planning a concert. | |
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I think the reluctance to seek professional help which, I agree, could have been kept on the down low was in part a consequence of disordered thinking caused by long-term drug abuse....it rewires the brain. | |
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Yes, but then maybe he really didn't want to stop? His associates probably wanted him to stop and was reaching out to people for help, but maybe he just wasn't interested and just going thru the motions with Dr. S. to get them off his back?? The only other thing he had in his life was his music and maybe he was tired of that too. | |
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RednBlue, I think you are spot-on re: Prince being more comfortable in the role of wisdom-giver/savior v. savee. Your thoughts on sleep equally insightful IMO.
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Thanks, peggyon. I would think everyone struggles with this balance to some degree. P often appeared confident in his wisdom. Seems like, combined with his other gifts, that could lead to wonderful things. For example, the seeds of potential he would see in people, and his desire to see those people grow and blossom. Just one area of P's great generosity.
[Edited 7/1/18 9:07am] | |
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I agree as well, he was clearly a generous spirit in many ways. | |
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And would NEVER deliberately take his own life no matter how much pain he was in.. "That mountain top situation is not really what it's all cracked up 2 B when was doing the Purple Rain tour had a lot of people who knew 'll never c again @ the concerts.just screamin n places they thought they was suppose 2 scream." | |
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rednblue said:
Yes! It is AMAZING how such a tender hearted man could have even attracted such fans who are vicious, judgemental and insulting people at their core. Very heartbreaking to learn he was reading this stuff on here. I almost don't blame him for being trapped in such a self conscious existence. | |
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Especially what he was reading here on the Org right before his death, and after Moline. | |
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when prince said...save your prayers etc.....FOR WHEN??? what did he think WOULD happen so we wouldnt have to pray??? | |
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luvsexy4all said: when prince said...save your prayers etc.....FOR WHEN??? what did he think WOULD happen so we wouldnt have to pray??? That statement still bugs me....i can't figure out what he meant by that. | |
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