Not really, more like anonymous folks on a gossip site, who have never met the patient. . Opioid use in rheumatoid ... (nih.gov) Rheumatologists are among the physicians at the forefront of the epidemic because of the prominent role of pain in rheumatoid arthritis (RA) and the limited options for treatment of pain. The purpose of this review is to provide an update on the trends of opioid use among patients with RA, to discuss the various mechanisms of RA pain, review the available evidence for opioid efficacy in RA, and to promote a guideline for best practices in opioid prescribing.
Recent findings: Recent cohort studies have estimated that up to 40% of patients with RA are regular users of opioids, and the effects of disease-modifying antirheumatic drugs are minimal in reducing opioid use.
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Prince had osteoarthritis, not rheumatoid arthritis. Both cause stiff, painful joints. Both are types of arthritis. Other than that, rheumatoid arthritis and osteoarthritis share little in common. Their differences begin with what causes them. Osteoarthritis is more commonly occurs later in life, after years of mechanical wear and tear on the cartilage which lines and cushions your joints. Rheumatoid arthritis, which can occur at most any age, is an autoimmune disease. That is, your body's immune system attacks your joints. *** I am not going to debate this further because you don't have the medical background. I am also going to ask nicely (once) that you stop following me like you did in another thread.
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You claimed that opiates are not the treatment - but many do take opiates for arthritis. I posted a response, because that is what one does on a disussion forum. You were not Prince's doctor, so have no more medical knowledge about him than anyone else here.
[Edited 4/10/21 21:46pm] | |
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Opioids for osteoarthritis | Cochrane
What is osteoarthritis and what are opioids? OA is a disease of the joints, such as your knee or hip. When the joint loses cartilage, the bone grows to try to repair the damage. Instead of making things better, however, the bone grows abnormally and makes things worse. For example, the bone can become misshapen and make the joint painful and unstable. This can affect your physical function or ability to use your knee. Opioids are generally conceived as powerful pain-relieving substances that are used for the pain of cancer or osteoarthritis. Some examples of opioids are codeine-containing Tylenol® (1, 2, 3, and 4), hydromorphone (Dilaudid), oxycodone (Percocet, Percodan), morphine, and others. They can be taken in a pill form, as an injection, or as a patch placed on the painful area.
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Margot said:
I don't agree with that statement . Many people in their mid-50's feel great; no aches or pains. It depends on how you've lived. Of course Prince and serious athletes can have traumatic arthritis. You must be a youngin then ...im almost 50 and i can tell you for a fact even many athletic people have ailments they in their feet muscles and etc so whatever u smoking please pass that around 🤣🤣🤣 i know a body builder and he has bad knees and still bodybuilds 🤣🤣🤣 [Edited 4/11/21 0:21am] Smurf theme song-seriously how many fucking "La Las" can u fit into a dam song
Proud Wendy and Lisa Fancy Lesbian asskisser | |
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Youv'e proven you can copy and paste from Web MD.
[Edited 4/11/21 0:41am] [Edited 4/11/21 0:50am] | |
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. Did you really think this through? Can you discern between root causes and side effects? Pain is simply an effect of something wrong somewhere. Taking away the pain (your 'treatment') does not fix the root cause. The root cause needs a different 'treatment' to be fixed. Pills and thrills and daffodils will kill... If you don't believe me or don't get it, I don't have time to try to convince you, sorry. | |
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None of that addresses addiction or tolerance build up, that's a different issue. | |
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. Thank you. . Anti-inflammatories are not the same as pain killers. (see dexmatheason and similar) .
. That is a problem created while not treating the root cause. Pills and thrills and daffodils will kill... If you don't believe me or don't get it, I don't have time to try to convince you, sorry. | |
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Yes, it is quite common to support claims with internet links, in this case from medical websites. But feel free to post your resume -- doesn't change the fact that many arthritis patients take opiates. It is one thing to have an opinion on a gossip forum, and quite another to declare what Prince did or didn't have, having never known or examined him. As for following you around, there is medication that can help. | |
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Once again, for the people in the back, taking high-dose opiates is not a recognized treatment for arthritis when there are many intermediate remedies. We also have no proof he had arthritis of the hands. Pure fan fiction.
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At the back of what, our avatar names? Opiates have indeed been a treatment for arthritis. As for the pain in Prince's hands -- it was Judith who put that out in her police report. But pictures of Prince's hands did look like he was struggling with arthritis. As for all of what he was dealing with, privacy laws apply to musicians too. | |
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None of the above is true. -Prince tried a procedure on one of hips, he decided against the other (though he needed it) -Please tell us which NSAIDS are in 'everything'? -There is no proof Prince had arthritis of the hands though he did play the piano hard.
Fentanyl is prescribed for post-operative pain and given (intravenously) in a recovery room. It is also used in patch form for end-of-life cancer-type pain.
Neither fentany nor Morphine have anti-infammatory properties...they are opiates, they are pain meds. -Anti-inflammatories are Advil, Motrin, Celebrex, steroids etc., NOT opiates. -Anti-inflammatories can and should used as a first-line drug, followed by Tylenol (unless one has liver or kidney issues). -Opiates are now given very sparingly as other drugs can be effective and are not addictive.
[Edited 4/13/21 20:21pm] [Edited 4/13/21 20:34pm] | |
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Frankly, as someone who has represented themself as a medical professional, and continued to make what would be controversial statements if you made them in a profresional setting, you've made a number of improper statements in this thread and past threads. Nuff said.
Neither of us knows the limitations of the arthritis Prince had or exactly how it effected his life. It's speculation. [Edited 4/14/21 0:32am] | |
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When you talk about medications, illnesses, you need to give it the same care that you would if you were talking to some of the engineers about reverb, compression, brickwalling or the folks in the Politics and Religion forum about political statements. Be specific, provide links. You can't say things like, 'anti-inflammatories are in everything' or Fentanyl and Morphine are anti-anflammatories.' They are not and what I am trying to do here is tighten up the loose talk that is pervasive on this site regarding medical, physiological, pharmacological topics. There are too many people saying things that fit their narrative and do not have basis. Sometimes you will not like it. It is not my intent to upset people, but to try to educate and bring some of the knowledge up to today's standards and current practices. Believe me, I wish there was someone else, an RN, MD, Pharmacist who could help me with this. I do not insert myself in topics that are above my knowledge base, for example, I would never talk loosely with some of the engineers. That is my time to listen. I try to be very careful when I know a previously-held belief is 'not holding water' as I know it will likely upset some fans. Believe it or not, I hold back quite a bit as I know there are entrenched beliefs here.
[Edited 4/14/21 7:27am] | |
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Unlike being an engineer with a niche set of knowledge, we all spend time with health issues or around people with health issues. There are nurses who are not confrnted with arthitic patients at all, whereas, some of us might have intimate knowledge about arthiritis specifically, not brain surgery, but arthritis, which is the topic. It's not reverb, it's the human body, which all of us have. | |
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DENTAL WORK!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Just trying to LIGHTEN up the conversation and say that I understand where Margot is coming from but why worry about it? Everything is supposed to be a learning experience. We can all become overzealous sometimes.
Welcome to "the org", heartpeacesheart…
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Alghedon Fentanyl Transde... (nih.gov) The efficacy of transdermal fentanyl for cancer pain and chronic non-cancer pain (chronic lower back pain, rheumatoid arthritis, osteoarthritis, neuropathic pain) is well established. ......... Benefits of transdermal f... (nih.gov)
Objectives: To evaluate the effectiveness and safety of transdermal fentanyl (TDF) for the treatment of pain associated with rheumatoid arthritis (RA) or osteoarthritis of the knee or hip (OA), which was not adequately controlled by non-opioid analgesics and/or weak opioids.
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Results: ....Pain control was increased from 4% to 29% of patients during run-in. The number of patients reaching adequate pain control in the first treatment week was increased to 75%, and increased further to 88% on day 28 and to 80% at endpoint. From baseline (screening) to endpoint, there were significant reductions in pain (p < 0.001) on the Wisconsin Brief Pain Inventory, and significant improvements in quality of life (Short-Form-36: physical p < 0.001; mental health p < 0.05). Eighty per cent of the patients (n = 134) assessed the treatment favourably; nausea and vomiting were the most common adverse events, mainly occurring at treatment initiation. Efficacy of metoclopramide appeared limited. TDF could be initiated in patients pre-treated with non-opioid analgesics or weak opioids and tapered off without major complications.
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Conclusions: TDF significantly improved pain control and quality of life, and was well tolerated in patients with RA or knee/hip OA who continued to experience pain on their current analgesic treatment. Treatment could be discontinued without issues. Nausea and vomiting was usually mild during treatment initiation. Patients' well being could be further accommodated by optimising prophylactic treatment.
.......... Transdermal fentanyl for ... (nih.gov) Background: This study was designed to evaluate the utility of transdermal fentanyl (TDF, Durogesic) for the treatment of pain due to osteoarthritis (OA) of the knee or hip, which was not adequately controlled by non-opioid analgesics or weak opioids. The second part of the trial, investigating TDF in patients with rheumatoid arthritis (RA) is reported separately. . Methods: Current analgesia was optimised during a 1-week run-in. Patients then received 28 days treatment with TDF starting at 25 microg/hr, with the option to increase the dose until adequate pain control was achieved. Metoclopramide was taken during the first week and then as needed. . Results: Of the 159 patients recruited, 75 with OA knee and 44 with OA hip completed the treatment phase, 30 knee and 18 hip patients entered the one-week taper-off phase. The most frequently used maximum dose of TDF was 25 microg/hr. The number of patients with adequate pain control increased during the run-in period from 4% to 27%, and further increased during TDF treatment to 88% on day 28. From baseline to endpoint, there were significant reductions in pain (p < 0.001) and improvements in functioning (p < 0.001) and physical (p < 0.001) and mental (p < 0.05) health. Scores for 'pain right now' decreased significantly within 24 hours of starting TDF treatment. TDF was assessed favourably and 84% of patients would recommend it for OA-related pain. Nausea and vomiting were the most common adverse events (reported by 32% and 26% of patients respectively), despite prophylaxis with metoclopramide, which showed limited efficacy in this setting. . Conclusion: TDF significantly increased pain control, and improved functioning and quality of life. Metoclopramide appeared to be of limited value in preventing nausea and vomiting; more effective anti-emetic treatment may enable more people to benefit from strong opioids such as TDF. This study suggests that four weeks is a reasonable period to test the benefit of adding TDF to improve pain control in OA patients and that discontinuing therapy in cases of limited benefit creates no major obstacles.
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I hope all the links I've posted have been educational. | |
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Interesting, arthritis, my favourite thing! One small comment - whether Prince's physical pain was derived from injuries (e.g. repetitive strain) or some form of arthritis or similar condition, tbh it's unhelpful and uncharitable to just write off his use of fentanyl as a mere chemical addiction. Chronic, constant pain has a weird way of rewiring your brain and changing how you see the world. When it gets to the point where even simple things in iife are painful and worsening each day, it's not just about addiction but also a desperation for normality, some respite. Anti-inflammatories, NSAIDs can help a little with flare-ups, and some folk get good results with ongoing immunosupressing treatments like DMARDs and biologics, but not for everyone - sometimes these treatments just make life harder in terms of nausea, tiredness etc (think, chemotherapy and you're on the right track). You can also become immune to the treatments and require bigger and bigger doses through no fault of your own.
I have psoriatic arthritis and honestly, even knowing what fentanyl did to Prince or Tom Petty, if I had their resources and I could access things like that, I'd be into it in a heartbeat. It's hard to explain how weird it is to have the constant presence of arthritic pain in your life, it starts to dominate your every waking thought. Even just a few hours break to play some guitar would be the best fucking thing in the world. Maybe cut Prince some slack on this. Especially if he was seeing a loss of things he really loved like dancing or playing guitar, I totally get it. That sucks. [Edited 4/14/21 23:50pm] | |
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Thanks for sharing ian, so sorry to hear about your struggles. | |
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Correction: He had become addicted to painkillers and was trying self-detox. | |
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Agreed. | |
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I wonder what the truth is. If someone back in the 90s didn't say to him, "Hey, Brother. Try one of these." And that was the beginning of a reliance on pills. This is not to blame anyone; I just had the thought that if we heard Prince tell his story now, what would it sound like? | |
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Margot has the career experience to back up her opinions, whilst she wasn't his doctor I do think her knowledge is far above all of us unless we share his conditions, or projected conditions. If it wasn't the usual way of dealing with the issue then it isn't the usual way. | |
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ian said: Interesting, arthritis, my favourite thing! One small comment - whether Prince's physical pain was derived from injuries (e.g. repetitive strain) or some form of arthritis or similar condition, tbh it's unhelpful and uncharitable to just write off his use of fentanyl as a mere chemical addiction. Chronic, constant pain has a weird way of rewiring your brain and changing how you see the world. When it gets to the point where even simple things in iife are painful and worsening each day, it's not just about addiction but also a desperation for normality, some respite. Anti-inflammatories, NSAIDs can help a little with flare-ups, and some folk get good results with ongoing immunosupressing treatments like DMARDs and biologics, but not for everyone - sometimes these treatments just make life harder in terms of nausea, tiredness etc (think, chemotherapy and you're on the right track). You can also become immune to the treatments and require bigger and bigger doses through no fault of your own.
I have psoriatic arthritis and honestly, even knowing what fentanyl did to Prince or Tom Petty, if I had their resources and I could access things like that, I'd be into it in a heartbeat. It's hard to explain how weird it is to have the constant presence of arthritic pain in your life, it starts to dominate your every waking thought. Even just a few hours break to play some guitar would be the best fucking thing in the world. Maybe cut Prince some slack on this. Especially if he was seeing a loss of things he really loved like dancing or playing guitar, I totally get it. That sucks. [Edited 4/14/21 23:50pm] Ian is right, We should cut P some slack. I don't know if you're a religous man Ian but I will pray for you to have relief. I hope this doesn't offend you in any way. Very interesting to read from a patient and a nurse perspective, love the. Diversity of the org. [Edited 4/22/21 15:30pm] | |
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MoodyBlumes said:
At the back of what, our avatar names? Opiates have indeed been a treatment for arthritis. As for the pain in Prince's hands -- it was Judith who put that out in her police report. But pictures of Prince's hands did look like he was struggling with arthritis. As for all of what he was dealing with, privacy laws apply to musicians too. Yes, it was Judith's report i got this from to start with. Wonder if she was a girlfriend, the girlfriend or a close friend to gain all that knowledge on arthritis. He didn't seem to tell the band even. | |
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Thanks so much for the kind words, I felt slightly embarrassed after posting all that but hey
Digging through Prince concert footage from the 2010s, it's pretty shocking to see how rapidly Prince's health declined in the final few years. Whatever was up there, I don't think any less of him for the way things ended. It's just desperately sad. Just goes to show, none of us know what is around the corner etc. Sorry, I'm being mister cheerful | |
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