OperatingThetan said:

onlyforaminute said:

Then Cat is faking who she says she is because what I said is that anyone faking their relationship with Prince to tell lies to fans is an assho**. If anyone can think I called Cat an assho** knows she really has been lying about who she is and in that case I don't care how anybody feels about it. I'm stanning for Prince not them. She only got called to carpet and decided to run instead that says all I really need to know.

Take your fight with Cat to another thread that you can create. Thanks.

I have been a Prince fan for 30 years but am fairly new to the org. Does that mean I am not a true fam? Not certain why there is that correlation?

peggyon said:

peggyon said:

PennyPurple said:

Only, I reported you for derailing this thread and your refusal to stop.

ThatWhiteDude said:

onlyforaminute said:

ThatWhiteDude said:

OperatingThetan said:

Everyone is entitled to their own opinion. They are not IMO entitled to their own 'facts' despite the strange times we are living in.

So here are some thoughts based on FACT as it relates to PRN's apparent long-time opioid use AND addiction.

FACT: an opioid receptor controls pain, reward and any behavior which can become addictive including sex, gambling, shoplifting, OCD, alcohol consumption, over-eating, etc.

FACT: Opioids ( like fentanyl) act on three receptors in the system. The MU receptor has the key component for triggering reward systems which initiate addictive behavior, usage craving and relapse . Opiate addicts who abuse this receptor by long term use present a high incident rate of depressive disorders that contribute to an addictive state of mind. The more this MU receptor is bombarded with an opiate, the more there is an increased sensitivity to pain ,altered emotional responses and a higher tolerance level for the opiate.

FACT: If you are a long term addict of opiates, you are not likely to have any control over this receptor. Once you dial back your consumption your pain will be greater and more intense.I am NOT referring to pain as we normally understand it: a broken bone, a burn, hip pain; I am referring to pain from withdrawals because the receptor is no longer able to control the neuro-transmitter that is messaging "pain". It has been rendered ineffective.

FACT: The second receptor, the NMDA receptor, is found in nerve cells. One of its primary functions is to govern neuropathic pain caused by a REDUCED FUNCTIONALITY of opioid receptors. This receptor is activated when patients require higher doses because of greater tolerance which in turn leads to a decrease in the opioid receptor's functionality mentioned above. Simply put, opioid resistance was a major problem Prince was struggling with. This is common with cancer patients, opiate addicts, etc.

There are some drugs that act upon the NMDA receptor by affecting the sodium channels in the receptor. Lidocaine is one of them. Therefore, Lidocaine is in fact an NMDA antagonist. Lidocaine is a sodium channel blocker. It binds the NMDA receptor in order to decrease the amount of nerve cells that are affected by messaging. These sodium channels exist in nerve cells only and therefore act upon peripheral nerve pain.

FACT: Lidocaine can be taken orally. While not administered/manufactured in pill form for oral consumption ,nor recommended by the manufacturer for oral consumption, it IS a compound that can be made into pill form. Some may believe that it is merely a cutting agent that "bulk" up sales....but but WHY would Prince possess and injest a Lidocaine laced pill specifically (rather than one laced with any other cutting agent)?BECAUSE when the fentanyl( or any other opiate) wears off, there was a decreased functionality in the opioid receptor which caused high sensitivity to pain .This activated the NMDA receptor which caused neuropathic nerve pain from overexcited nerve cells.

Lidocaine was used by Prince to regulate the sodium channel passing thru the nerve cells which in turn decreases perception to pain without the withdrawal effects of that produced by fentanyl.

Prince was operating way outside the norm of street manufacturing protocol. He was smart, experienced, rich, stubborn, ALWAYS did what he wanted his own way...and paid the ultimate price. RIP.

[Edited 8/5/18 11:17am]

paulludvig said:

Yes, hopefully the mods will look into possible multiple accounts.

You've made accusations but have yet to say who those accusations are against, even when you were asked. My advise to you was to report it to the mods. Since you are so worried about it, hopefully you will follow thru.

OperatingThetan said:

onlyforaminute said:

Bodhitheblackdog said:

Thanks for posting that Bodhi. I'm afraid it will just get lost in the fray, that has become this thread. You might want to screenshot it or copy it, so we'll have it as a reference. That does help explain about the lidocaine.

Bodhitheblackdog said:

Everyone is entitled to their own opinion. They are not IMO entitled to their own 'facts' despite the strange times we are living in.

So here are some thoughts based on FACT as it relates to PRN's apparent long-time opioid use AND addiction.

FACT: an opioid receptor controls pain, reward and any behavior which can become addictive including sex, gambling, shoplifting, OCD, alcohol consumption, over-eating, etc.

FACT: Opioids ( like fentanyl) act on three receptors in the system. The MU receptor has the key component for triggering reward systems which initiate addictive behavior, usage craving and relapse . Opiate addicts who abuse this receptor by long term use present a high incident rate of depressive disorders that contribute to an addictive state of mind. The more this MU receptor is bombarded with an opiate, the more there is an increased sensitivity to pain ,altered emotional responses and a higher tolerance level for the opiate.

FACT: If you are a long term addict of opiates, you are not likely to have any control over this receptor. Once you dial back your consumption your pain will be greater and more intense.I am NOT referring to pain as we normally understand it: a broken bone, a burn, hip pain; I am referring to pain from withdrawals because the receptor is no longer able to control the neuro-transmitter that is messaging "pain". It has been rendered ineffective.

FACT: The second receptor, the NMDA receptor, is found in nerve cells. One of its primary functions is to govern neuropathic pain caused by a REDUCED FUNCTIONALITY of opioid receptors. This receptor is activated when patients require higher doses because of greater tolerance which in turn leads to a decrease in the opioid receptor's functionality mentioned above. Simply put, opioid resistance was a major problem Prince was struggling with. This is common with cancer patients, opiate addicts, etc.

There are some drugs that act upon the NMDA receptor by affecting the sodium channels in the receptor. Lidocaine is one of them. Therefore, Lidocaine is in fact an NMDA antagonist. Lidocaine is a sodium channel blocker. It binds the NMDA receptor in order to decrease the amount of nerve cells that are affected by messaging. These sodium channels exist in nerve cells only and therefore act upon peripheral nerve pain.

FACT: Lidocaine can be taken orally. While not administered/manufactured in pill form for oral consumption ,nor recommended by the manufacturer for oral consumption, it IS a compound that can be made into pill form. Some may believe that it is merely a cutting agent that "bulk" up sales....but but WHY would Prince possess and injest a Lidocaine laced pill specifically (rather than one laced with any other cutting agent)?BECAUSE when the fentanyl( or any other opiate) wears off, there was a decreased functionality in the opioid receptor which caused high sensitivity to pain .This activated the NMDA receptor which caused neuropathic nerve pain from overexcited nerve cells.

Lidocaine was used by Prince to regulate the sodium channel passing thru the nerve cells which in turn decreases perception to pain without the withdrawal effects of that produced by fentanyl.

Prince was operating way outside the norm of street manufacturing protocol. He was smart, experienced, rich, stubborn, ALWAYS did what he wanted his own way...and paid the ultimate price. RIP.

[Edited 8/5/18 11:17am]

Bodhitheblackdog said:

Everyone is entitled to their own opinion. They are not IMO entitled to their own 'facts' despite the strange times we are living in.

So here are some thoughts based on FACT as it relates to PRN's apparent long-time opioid use AND addiction.

FACT: an opioid receptor controls pain, reward and any behavior which can become addictive including sex, gambling, shoplifting, OCD, alcohol consumption, over-eating, etc.

FACT: Opioids ( like fentanyl) act on three receptors in the system. The MU receptor has the key component for triggering reward systems which initiate addictive behavior, usage craving and relapse . Opiate addicts who abuse this receptor by long term use present a high incident rate of depressive disorders that contribute to an addictive state of mind. The more this MU receptor is bombarded with an opiate, the more there is an increased sensitivity to pain ,altered emotional responses and a higher tolerance level for the opiate.

FACT: If you are a long term addict of opiates, you are not likely to have any control over this receptor. Once you dial back your consumption your pain will be greater and more intense.I am NOT referring to pain as we normally understand it: a broken bone, a burn, hip pain; I am referring to pain from withdrawals because the receptor is no longer able to control the neuro-transmitter that is messaging "pain". It has been rendered ineffective.

FACT: The second receptor, the NMDA receptor, is found in nerve cells. One of its primary functions is to govern neuropathic pain caused by a REDUCED FUNCTIONALITY of opioid receptors. This receptor is activated when patients require higher doses because of greater tolerance which in turn leads to a decrease in the opioid receptor's functionality mentioned above. Simply put, opioid resistance was a major problem Prince was struggling with. This is common with cancer patients, opiate addicts, etc.

There are some drugs that act upon the NMDA receptor by affecting the sodium channels in the receptor. Lidocaine is one of them. Therefore, Lidocaine is in fact an NMDA antagonist. Lidocaine is a sodium channel blocker. It binds the NMDA receptor in order to decrease the amount of nerve cells that are affected by messaging. These sodium channels exist in nerve cells only and therefore act upon peripheral nerve pain.

FACT: Lidocaine can be taken orally. While not administered/manufactured in pill form for oral consumption ,nor recommended by the manufacturer for oral consumption, it IS a compound that can be made into pill form. Some may believe that it is merely a cutting agent that "bulk" up sales....but but WHY would Prince possess and injest a Lidocaine laced pill specifically (rather than one laced with any other cutting agent)?BECAUSE when the fentanyl( or any other opiate) wears off, there was a decreased functionality in the opioid receptor which caused high sensitivity to pain .This activated the NMDA receptor which caused neuropathic nerve pain from overexcited nerve cells.

Lidocaine was used by Prince to regulate the sodium channel passing thru the nerve cells which in turn decreases perception to pain without the withdrawal effects of that produced by fentanyl.

Prince was operating way outside the norm of street manufacturing protocol. He was smart, experienced, rich, stubborn, ALWAYS did what he wanted his own way...and paid the ultimate price. RIP.

[Edited 8/5/18 11:17am]

So are we saying that Prince created his own pills?

Also, Lidocaine is used topically, and can leach into the system. It used for skin irritations, such as mosquito bites (he was just in Atlanta, where the mosquitoes are bigger than houses), and it is also used to treat rectal discomfort, such as that caused by hemorrhoids (which is possible that he had since he was constipated and using enemas).

[Edited 8/5/18 11:54am]

Bodhitheblackdog said:

Bodhi gave some good information in his post, stating "let's stick with the facts" but then ended that post on supposition. He has no way of knowing how or why Prince was using Lidocaine. Prince could have been using it to treat hemorrhoids, or he could have been using it to treat a skin disturbance.

benni said:

benni said:

Bodhi gave some good information in his post, stating "let's stick with the facts" but then ended that post on supposition. He has no way of knowing how or why Prince was using Lidocaine. Prince could have been using it to treat hemorrhoids, or he could have been using it to treat a skin disturbance.

Wouldn't that be lidocaine in cream form? Because the lidocaine that was found at PP was in pill form.

PennyPurple said:

paulludvig said:

onlyforaminute said:

PennyPurple said:

benni said:

Bodhi gave some good information in his post, stating "let's stick with the facts" but then ended that post on supposition. He has no way of knowing how or why Prince was using Lidocaine. Prince could have been using it to treat hemorrhoids, or he could have been using it to treat a skin disturbance.

Wouldn't that be lidocaine in cream form? Because the lidocaine that was found at PP was in pill form.

Yes, I'm looking at the creams. According to Wikipedia, lidocaine is only offered as a: Lidocaine, usually in the form of lignocaine hydrochloride, is available in various forms including many topical formulations and solutions for injection or infusion.

No where have I been able to find Lidocaine as a pill form.

As for street uses:


Names[edit]

Lidocaine is the INN and BAN while lignocaine is the AAN and former BAN.

Xylocaine is a brand name.

Recreational use[edit]

Lidocaine is not currently listed by the World Anti-Doping Agency as an illegal substance.[44] It is used as an adjuvant, adulterant, and diluent to street drugs such as cocaine and heroin.[45] It is one of the three common ingredients in site enhancement oil used by bodybuilders.[46]

Adulterant in cocaine[edit]

Lidocaine is often added to cocaine as a diluent.[47][48] Cocaine numbs the gums when applied. Lidocaine causes a similar numbing sensation when applied to the gums and is sometimes used as an adulterant in cocaine. This gives the user the impression of high-quality cocaine when in actuality, the user is receiving a diluted product.[49]

[Edited 8/5/18 12:52pm]