I have read what Mayte had to say about her marriage to prince in past interviews. She did say that sometimes things happened that drive a couple apart (the sad loss of their child). With Prince being a believer of the Jehovah's witness faith. (Please understand I am not attacking anyone's religion. This is just a thought that entered my mind) If this added to the problems of the marriage especially concerning some of the Jehovah's witnesses believe regarding healthcare and treatment.

health care and treatment regarding their child? that child was born with its brain exposed. fatality was a given.

wow, talk about a misleading thread title.

sosgemini said:

Thank you!

What a tough question, don't you think? What is a baby's chance to survive Pfeiffer syndrome with or without treatment? Is there anything doctors can do against this disease?

I strongly recommend getting some information before posting such words. It's a very sensitive subject.

I have posted in the past lengthy data on the subject. To summarize:
There are 3 clinical subtypes based on the severity of the phenotype.
Classic Pfeiffer syndrome, type I, involves individuals with mild manifestations, associated with normal neurological and intellectual development. The outcome is genereally good.
Type II consists of cloverleaf skull, Pfeiffer hands and feet, severe exorbitism, central nervous system involvement, and elbow ankylosis or synostosis.
Type III is similar to TypeII without the cloverleaf skull.
The prognosis for types II and III is poor due to neurological compromise and varietous visceral abnormalities, and generally result in early death.
This info is from the Sao Paulo Medical Journal 2003.
[Edited 4/28/07 13:10pm]

"Bad Gateway", so I double posted.
[Edited 4/28/07 13:09pm]

Why is Mani's name in the title?

malbena said:

Only Type I has a good outcome.
Types II and III are not treatable.
Pfeiffer Syndrome is a autosomal dominant disorder that can be caused by mutations in the fibroblast growth factor receptor 2(FGFR2) gene.
The disorder is sporadic and rare and risk of future children with the disorder is minimal.
Prenatal diagnosis can be made with 3-D ultrasound based on head shape, hand and foot abnormalities. Unfortunately, clinical management has major problems.

xplnyrslf said:

i wonder if prince and mayte knew the condition prior to birth. and which type was baby brian?

PurpleCharm said:

that's why I posted the title was misleading. I thought I was going to read about something else.

I meant compiled with stress of this and everything else pushed Prince and Mayte away from each other and to other people. Especially Mani because wasn't she already a Jehovah's witness which created a common bond for her and Prince.
[Edited 4/28/07 14:25pm]
[Edited 4/28/07 14:29pm]
[Edited 4/28/07 14:30pm]

sosgemini said:

I'm assuming Type II or III.
The article I have says prenatal diagnosis can occasionally be made with 3-D ultrasound based on ultrasound findings like head shape, facial , hand, and foot abnormalities.
So, 1st a regular ultrasound is done and if abnormalities are seen ,3-D is done which is more detailed. It depends on whether Mayte had an ultrasound that picked up anything unusual. And it was pursued.

sosgemini said:

4: Blaumeiser B, Loquet P, Wuyts W, Nothen MM.
Related Articles, Links


Prenatal diagnosis of Pfeiffer syndrome type II.
Prenat Diagn. 2004 Aug;24(8):644-6.
PMID: 15305355 [PubMed - indexed for MEDLINE]
Pfeiffer syndrome is an autosomal dominant disorder characterized by coronal craniosynostosis, midface hypoplasia, broad thumbs and great toes. On the basis of clinical findings, three subtypes have been delineated. The clinical variability of Pfeiffer syndrome as well as other causes of craniosynostosis can make a prenatal diagnosis based on sonography alone difficult. We describe a fetus in whom sonographic findings (including 3D ultrasound) suggested a Pfeiffer syndrome type II and in which subsequent molecular analysis verified the diagnosis by identifying a de novo mutation in the FGFR2 gene. To the best of our knowledge, this is the first report of a prenatal molecular diagnosis of Pfeiffer syndrome in a patient without family history.