Mach said:

No shit, it's silly to use somethign as expensive like cocaine just to numb your genitals.



Cheaper and safer.

Of if you need something stronger:

[Edited 8/24/09 16:46pm]

I always stayed away from it. The odd thing about drugs is that outgoing people use coke & quiet people smoke weed.

It should probably be the other way around.

sermwanderer said:

It's not an "invention" it occurs naturally in the coca plant.

Imago said:

amen

MIGUELGOMEZ said:

I agree meth is worse. You have to cook up meth from toxic chemicals. SO why would you then turn around and ingest it? I just stay away.

CarrieMpls said:

If that were the case, Miami would be empty.
I don't think they cancel each other out either. I would venture to guess it would be a boost to the alcohol. Alcohol may be classified as a depressant chemically, but people don't go to bars because they're insomniacs.

eikonoklastes said:

Cocaethylene: Immunologic, Hepatic, and Cardiac Effects


Concomitant cocaine and ethanol use produce the compound cocaethylene. A 1995 study estimated that 60 to 80 percent of cocaine users consume ethanol simultaneously. Some users of cocaine mix it with ethanol together as they extend the euphoric sensation and lessen the dysphoria associated with a cessation of cocaine. Cocaethylene, a compound synthesized in vivo, was only identified in 1979. It also has been named in literature as ethylcocaine, ethylbenzoylecgonine, and benzoylecgonine ethyl ester. In 1990, an NIAAA Survey reported that 5.3 million Americans had used cocaine concurrently (during the same period of time) with alcohol, and 4.6 million simultaneously (on the same occasion) with ethanol.

Although the mechanism by which the combination of cocaine and ethanol may be particularly deleterious to the cardiovascular system is unknown, two hypotheses have been proposed:

It may markedly increase the determinants of myocardial oxygen demand and simultaneously diminish supply, leading to a marked supply:demand imbalance; in human volunteers, the use of both drugs produces a greater increase in heart rate than either substance alone.
The concomitant ingestion of cocaine and ethanol may lead to the production of a metabolite which induces marked coronary arterial vasoconstriction, leading to myocardial ischemia, infarction, and/or sudden death.
While formed when cocaine and ethanol were consumed simultaneously in humans, monkeys, and mice, formation of cocaethylene resulted through transesterification of cocaine by hepatic carboxylesterases in the liver. Further studies must be done in species that resemble humans to determine the pathways and significance of the cocaine and ethanol combination.

The toxicity that results from combined cocaine and ethanol use is not due to enhanced sensitivity to alcohol in cocaine abusers. In rats cocaethylene exposure during the brain growth spurt period causes teratogenic effects slowing brain growth. Cocaethylene is a neuroteratogen as indicated by altered concentrations of catecholamines and indoleamines in developing brains. There was a region-specific alteration in neurotransmitter levels in response to six days of cocaethylene exposure. It also appears that cocaethylene is more similar to ethanol than cocaine in terms of neuroteratogeneis. Measured cocaine and cocaethylene concentration in postmortem human cerebral cortex and that combined use of cocaine and ethanol increased the risk of death 18-fold.

In the first primate study the effects of intravenously administered cocaine on extracellular dopamine in the primate was compared to the effects of cocaethylene. There are numerous biochemical and pharmacological differences between primates, rodents and dogs that make it important to study primates if immediate extensions to clinical research studies in humans are to be made. Both cocaethylene and cocaine are equipotent and were found to increase extracellular dopamine in the caudate nucleus. Cocaethylene retains activity similar to cocaine including inhibition of dopamine transporter. In most case studies, the potentiality of cocaine and cocaethylene seem to point to equal potency in in vitro experiments. The organs of 60 percent of the addicts seeking medical attention in emergency rooms, or examined postmortem specimens, contain cocaethylene.

BIBLIOGRAPHY

CHEN, W. J. A., & WEST, J. R.. (1997). Cocaethylene exposure during the brain growth spurt period: Brain growth restrictions and neurochemisty studies. Developmental Brain Research, 100: 220-229.

PIROZHKOV, S.V.& WATSON, R. R. P.. (1993). Immunomodulalting and hepatotoxic effects of cocaine and coaerthylene: enhancement by simultaneous ethanol administration. Alcologia, 5: 113-116.

SONG, N., PARKER, R. B., & LAIZURE, C. S. (1999). Cocaethylene formation in rat, dog, and human hepatic microsomes. Life Sciences, 64: 2101-2108.

ALBERT D. ARVALLO

RONALD ROSS WATSON

http://www.enotes.com/dru...ac-effects


In short, bad things tend to happen to people who use alcohol with cocaine. Being an addict . . . it doesn't say cocaine, alcohol or both . . .
I don't think it's worth increasing my risk of death 18 fold to party with alcohol and cocaine.

ehuffnsd said:

No experience with pnp here. I think I have too many hang-ups for that.

eikonoklastes said:

gross. a few years back I had some friends get into that mess. I've had it in my mouth cuz it like... I dunno, I think they said it was suppose to make my mouth numb or some shit BLAH, I still feel dirty til this day from even doing that much.

Serious said:

I agree.

SUPRMAN said:

I know that, but the average gram of Cocaine isn't pure Cocaine

The coca leaf is also subject to numerous chemical treatments to extract the cocaine compound. so you know what i mean.

cheers though

sermwanderer said:

exactly, that white powder is not just fruit that fell from the coca plant!

I've had a couple of opportunities in my life to snort all the coke I wanted - FOR FREE (associating with band members and/or drug dealers that kept that shit around on a regular). I won't lie, the HIGH was wonderful. The high always made me feel like I had just won the lottery or some shit, lol. Heart pumping like I was on that first dip of a roller coaster. But the thing is: That feeling only lasted about 10-15 minutes tops, and subsequent toots never quite brought me back up to that level during that same session. And it seemed to me that enough would never be enough.

But then the thing that I really, really, really didn't like about it was - after the high wore off, I'd sink into a major depression for the next 2 days, lol. That DID IT for me, lol. Luckily, it never hooked me like it did everyone else around me. When it was gone, I didn't miss it. And I was NEVER about to spend one dollar on that nonsense. Then on top of that, I noticed everyone else around me falling apart at the seams over that shit. When I saw THAT (friends selling their cars, homes, & booty-holes), the coffee was ON, and I got a good whiff... NO MORE. And that was nearly 20 years ago. I only see cocaine as something that destroys lives, dreams, and bank accounts.

PDogz said:

Only if U allow it to.

The same could be said for other addictions...ie. gambling.

PanthaGirl said:

true, I know people who use it sometimes and their lives didn't fall apart. And I know people who fuck up their lives with weed or alcohol. It depends on the person.

NDRU said:

Absolutely...

NDRU said:

Totally.

PanthaGirl said:

I would agree, and I wasn't about to allow it to. I also agree that all addictions are more alike than they are different.

heybaby said:

I really don't see how this is hypocritical of me, considering that I have absolutely no tolerance of addicts exactly because of my past, seeing as how I grew up with parents addicted to various substances. Please explain to me how it's hypocritical to have no tolerance of this issue as well? It feels very consistent to me. For anybody to portray a drug as harmless, which is more or less what is said on this thread, is dumb beyond belief. I don't accept any kind of misfortune as an excuse to take drugs or get addicted to them, with the possible exception of if you're having a gun held to your head to make you ingest the drug - imminent physical harm, that is. Otherwise, no. If I'd believed it made things better I would most likely have been addicted to all sorts of drugs before the age of 15, but growing up with it so close I could easily see it's nothing but bad, regardless of which drug/s you take. It's incredibly dangerous to depict any drug as harmless or less dangerous than another, because some people will believe it - somebody reads some of the shit here, they go out and try coke rather than meth when given a choice... and they happen to be one of those people who die on the first try, or it turns out to be their body's drug of choice and they're hooked for life.
Incidentally, your last sentence is in a way the essence of the drug problem - very few people try drugs on their own, they do it (just like so many things) because their friends do it, with or without the presence of peer pressure - because they want to be liked by other people. There's also the semblence of safety when you do drugs with your friends, but it's all a sham.
To sum it up... "drugs are bad, mmmkay?"

Teacher said:

I don't see any body on this board sayin that drugs are good but nice try with your attempts at patronizing me-not gonna happen and I'm not your child or one of your dogs mmmkay?. Its hypocritical considering that you have problems too. You expect compassion and understanding so give it in return. Do unto others as you would want them to do to you. The statement you made "One can only hope. Those deaths would not be a tragedy" was very harsh. But you want or expect sympathy? What if somebody said that about your mental issues? That would be wrong. think about it. But I know you won't so talk to yourself (no pun intended).

heybaby said:

PDogz said:

hell, yeah i had the same experience

and did an 8 ball once and the high was even better (best in my life) and the depression afterwards even worse

i think everyone should try everything at least once but that is where it ends with drugs all you kids out there

japanrocks said:

Based on everything that's been said here about cocaine, u still think everyone should try it at least once?

I would never encourage anyone to try any kind of drug for ‘just once, to see what it’s like’.

I do however, believe that it is your own responsibility should you want to try it. But get informed, get educated about that stuff. Whatever substance you use, whether alcohol or class a drugs, there is always a risk that you get addicted to them.

You have to realize that the high you’ve experienced the first time will never come back, no matter how much shit you snort or how many pills you swallow.

I’ve tried a wide variety of drugs, mostly it were good experiences and sometimes it was just absolutely fucking great. But I do realize that whatever I was feeling or experiencing at the time was induced by chemicals. So none of it was truly real.

And thank Allajehovajezusmarygodandtherestofthem for the worst hangovers ever! The hangovers are severe and you can get really depressed after you’ve come down again.

If it wasn’t for the hangovers I might’ve been more inclined to use drugs on a regular basis. But take this from me, nothing beats the feeling of having a clear mind!

It did what I wanted it to do which was to numb my feelings.

Drugs are 4 losers.....

MacDaddy said:

The likelihood is too high that you'll want to try it once more, then once more, then just once more, then... (you get the idea, lol)

MacDaddy said:

Not saying everyone that tries drugs will become addicted, but many drug addicts got started because they just wanted to "try it once". KNOW THAT.

MacDaddy said:

...then the problem here is: The FIRST idea that will come to your mind to counteract the SEVERE DEPRESSION you WILL experience after coming down... is to do more of that drug that made you feel so wonderful to begin with. The sick part is: you'll never feel that first high again (...but it won't stop you from trying, lol).

Reading the comments here, it just seems screwing with coke is the fast track to an acute bipolar episode.

I think I'll pass.