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Heroin vs. Fentanyl - the deadlier explained I'm not trying to open a debate on how Prince died. Like many, I didn't know much about Fentanyl, other than a name of yet another narcotic I'll never have in my body. This report on PBS popped up in my Facebook feed earlier today, and I thought I'd share it here. Ironically, Prince is not mentioned in the article, but it's obviously this could have spawned from his death.
It’s deadly because it’s so much stronger than heroin, as shown by the photograph above, which was taken at the New Hampshire State Police Forensic Laboratory. On the left is a lethal dose of heroin, equivalent to about 30 milligrams; on the right is a 3-milligram dose of fentanyl, enough to kill an average-sized adult male. The difference in strength between heroin and fentanyl arises from differences in their chemical structures. The chemicals in both bind to the mu opioid receptor in the brain. But fentanyl gets there faster than morphine — the almost-instantaneous byproduct when the body breaks down heroin — because it more easily passes through the fat that is plentiful in the brain. Fentanyl also hugs the receptor so tightly that a tiny amount is enough to start the molecular chain of events that instigates opioids’ effects on the body. This tighter affinity for the opioid receptor also means more naloxone — or Narcan — may be needed to combat a fentanyl overdose than a heroin overdose. “In a fentanyl overdose, you may not be able to totally revive the person with the Narcan dose you have,” said Scott Lukas, director of the Behavioral Psychopharmacology Research Laboratory at McLean Hospital in Belmont, Mass. “Naloxone easily knocks morphine off of the receptor, but does that less so to fentanyl.”
[Edited 10/1/16 12:07pm] "  don’t really care so much what people say about me because it is a reflection of who they r." |
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TrivialPursuit said: I'm not trying to open a debate on how Prince died. Like many, I didn't know much about Fentanyl, other than a name of yet another narcotic I'll never have in my body. This report on PBS popped up in my Facebook feed earlier today, and I thought I'd share it here. Ironically, Prince is not mentioned in the article, but it's obviously this could have spawned from his death.
It’s deadly because it’s so much stronger than heroin, as shown by the photograph above, which was taken at the New Hampshire State Police Forensic Laboratory. On the left is a lethal dose of heroin, equivalent to about 30 milligrams; on the right is a 3-milligram dose of fentanyl, enough to kill an average-sized adult male. The difference in strength between heroin and fentanyl arises from differences in their chemical structures. The chemicals in both bind to the mu opioid receptor in the brain. But fentanyl gets there faster than morphine — the almost-instantaneous byproduct when the body breaks down heroin — because it more easily passes through the fat that is plentiful in the brain. Fentanyl also hugs the receptor so tightly that a tiny amount is enough to start the molecular chain of events that instigates opioids’ effects on the body. This tighter affinity for the opioid receptor also means more naloxone — or Narcan — may be needed to combat a fentanyl overdose than a heroin overdose. “In a fentanyl overdose, you may not be able to totally revive the person with the Narcan dose you have,” said Scott Lukas, director of the Behavioral Psychopharmacology Research Laboratory at McLean Hospital in Belmont, Mass. “Naloxone easily knocks morphine off of the receptor, but does that less so to fentanyl.”
Thanks for the info. Very interesting. I work in healthcare and still find it difficult to fully understand the different opiates and their unique characteristics. It's sad that fentanyl has found its way out of a healthcare facility setting. It's much too dangerous on the streets. I can't imagine addicts survive long w/o intervention. The effects of fentanyl don't last as long and addicts are basically almost continually coming down and its that part of the cycle that drives the addiction. It's that constant need, craving, drive for more to prevent coming down that's the big problem. It's a hurtful place, the world, in and of itself. We don't need to add to it. We all need one another. ~ PRN | |
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You think those are bad......... This is the new street drug and it is the 'bad boy' http://www.cbc.ca/news/he...-1.3769774 
Ohh purple joy oh purple bliss oh purple rapture! REAL MUSIC by REAL MUSICIANS - Prince "I kind of wish there was a reason for Prince to make the site crash more" ~~ Ben |
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" don’t really care so much what people say about me because it is a reflection of who they r." |
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I dunno why folks do this crap by frying their brain cells and fucking up their bodies. Many reasons I suppose such as depression, want to get an adrenalin rush of a high. Who knows.
Ohh purple joy oh purple bliss oh purple rapture! REAL MUSIC by REAL MUSICIANS - Prince "I kind of wish there was a reason for Prince to make the site crash more" ~~ Ben |
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It's really not very complicated. Whenever humans do something that they enjoy, certain chemicals are released in the brain. The by-product of the processing and metabolization of those brain chemicals, is the brain perceiving sensations of pleasure. A lot of different things produce those pleasure-inducing brain chemicals...
I assume that everybody gets at least some amount of pleasure from at least one of those things listed above. So, all you have to do is assign a number from a scale of 1 to 10 to represent the degree of pleasure you get from whatever it is you can relate to from the above list — {or anything else you can imagine that's not on the above list}. Then multiply that number by several million. Now imagine how much greater a degree of pleasure that would be. The degree of pleasure produced in the brain by opioids, is off the charts! That should give you an idea of why addictive substances have such an appeal to so many. [Edited 10/1/16 13:20pm] “Sometimes People Don't Want To Hear The Truth Because They Don't Want Their Illusions Destroyed” — Friedrich Nietzsche | |
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Yeah, I've read some stuff about this new drug disaster Welcome to "the org", Mumio…they can have you, but I'll have your love in the end  | |
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" don’t really care so much what people say about me because it is a reflection of who they r." |
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The intention of my post was to answer your question, "Why do people do these?!?!?!?!?!". To summarize my answer more succinctly: "People do those because those drugs supercharge the production of pleasure-inducing brain chemicals" If you reread my post carefully, you'll see that I didn't say everything in that list are chemicals. That is you should see. Unless you understand, "sex and reading produces pleasure-inducing chemicals in the brain", to mean exactly the same thing as, "sex and reading are chemicals". If that is how you interpreted what I wrote, then...Well...What can I say? You can't say that I didn't at least try to answer your question.
Evidently so. There are also obvious gaps in your knowledge when it comes to the neurochemicals the brain produces too. [Edited 10/1/16 17:50pm] “Sometimes People Don't Want To Hear The Truth Because They Don't Want Their Illusions Destroyed” — Friedrich Nietzsche | |
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" don’t really care so much what people say about me because it is a reflection of who they r." |
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luv4u said: You think those are bad..... This is the new street drug and it is the 'bad boy' http://www.cbc.ca/news/he...-1.3769774 That's crazy. There are a lot of broken people walking amongst us tying to ease the pain. Unless you've taken opiates it's hard to adequately describe the feeling of euphoria they produce. It doesnt matter what horrible shit is really going on around you; life is all good when you're high on pain pills. Consider that a man can get his leg blown off in combat and morphine can make it all better. That's some powerful mind bending stuff. Worse is that opiate addiction is a two - headed beast. Hard enough getting someone living a bleak existence to quit using opiates after experiencing, possibly for the first time, an intense overall sense of well being. Add to that the brutal symptoms the rest of your body is experiencing when you quit taking opiates. Both psychological and physical dependence to deal with. It's not that hard to imagine how it happens in the first place. Or why it's so hard to quit. [Edited 10/2/16 2:12am] It's a hurtful place, the world, in and of itself. We don't need to add to it. We all need one another. ~ PRN | |
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[Snip - luv4u] “Sometimes People Don't Want To Hear The Truth Because They Don't Want Their Illusions Destroyed” — Friedrich Nietzsche | |
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" don’t really care so much what people say about me because it is a reflection of who they r." |
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"Music gives a soul to the universe, wings to the mind, flight to the imagination and life to everything." --Plato
https://youtu.be/CVwv9LZMah0 | |
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Like with a lot of cases, the people who overdose from fentanyl or carfentanil don't know they are ingesting those. They buy one opioid, unaware it contains another, deadlier opioid. It's such a scary situation. "She made me glad to be a man" | |
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I watched a documentary on this drug after Prince died, and it was so interesting because it was about how the drug came to be, the pharmaceutical companies that market this drug, and also the addicts that were addicted to this powerful drug. It was very informative, and I know absolutely nothing about drugs, and they will never enter my body. But it was very eye-opening. And in my area, this documentary was on the Fusion channel. The documentary is called Naked Truth: Death by Fentanyl, if anyone would like to check it out. Erin Smith | |
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